LEUCEMIA AGUDA MIELOIDE · DNMT3A (R882) · HOT SPOT

LEUCEMIA AGUDA MIELOIDE · WT1(SOBREXPRESION) · RT-PCR

LEUCEMIA MIELOIDE AGUDA · U2AF1 (EXONES 2, 6) · HOT SPOT

Cariotipo de médula ósea

FISH (AML1,ETO) t(8,21)

FISH (BCR,ABL) t(9,22)

FISH (CBF-B/MYH11) inv(16)/t(16;16)

FISH (EVI)t(3,3)

FISH (MLL) t(11q23)

FISH (PML,RARA)t(15,17)

Panel neoplasia mieloide. SNVs: ARID5B, ASXL1, ASXL2, ATRX, BCOR, BCORL1, BLNK, BRAF, CALR, CBL, CDKN2A, CDKN2B, CEBPA, CHIC2, CREBBP, CSF3R, CSNK1A1, CUX1, DDX3X, DDX41, DNMT3A, EP300, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GATA3, HAVCR2, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK2, JAK3, KIT, KMT2A, KMT2C, KRAS, MPL, NF1, NFE2, NOTCH1, NPM1, NR3C1, NRAS, P2RY8, PAX5, PHF6, PIGA, PPM1D, PTEN, PTK2B, PTPN11, RAD21, RB1, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRP72, SRSF2, STAG1, STAG2, STAT5B, TET2, TP53, TYK2, U2AF1, WT1, ZRSR2 Fusiones: ABL1, ABL2, BCR, CBFA2T3, CBFB, CSF1R, EPOR, ETV6, FGFR1, FUS, JAK2, KMT2A, MEF2D, MNX1, MYH11, NPM1, NUP214, NUP98, PDGFRA, PDGFRB, RARA, RBM15, RUNX1, SETBP1, STIL, TAL1, TCF3 CNVs

Panel oncohematológico (linfomas y mielomas). SNVs: ABL1, ANKRD26, ARID1A, ARID2, ASXL1, ATM, B2M, BCL2, BCL6, BCOR, BCORL1, BCR, BIRC3, BRAF, BTG1, BTG2, BTK, CALR, CARD11, CBL, CCND3, CD58, CD79A, CD79B, CDKN2A, CDKN2B, CEBPA, CREBBP, CSF3R, CSNK1A1, CUX1, CXCR4, DDX3X, DDX41, DNMT3A, EBF1, EGR2, EP300, ERG, ETV6, EZH2, FBXW7, FLT3, FOXO1, GATA1, GATA2, GNA13, GNAQ, HRAS, ID3, IDH1, IDH2, IKZF1, IRF4, JAK1, JAK2, JAK3, KIT, KLF2, KMT2A, KMT2C, KMT2D, KRAS, MAP2K1, MECOM, MEF2B, MGA, MPL, MYC, MYD88, NF1, NFKBIE, NOTCH1, NOTCH2, NPM1, NRAS, NT5C2, PAX5, PDGFRA, PHF6, PIK3CA, PIK3CD, PIK3CG, PIM1, PLCG2, POT1, PPM1D, PRDM1, PSMB5, PTEN, PTPN11, RAD21, RHOA, RPN1, RPS15, RUNX1, SAMD9, SBDS, SESN1, SETBP1, SETD2, SF1, SF3A1, SF3B1, SMC3, SOCS1, SOCS2, SRSF2, STAG2, STAT3, STAT5B, TCF3, TENT5C, TERT, TET2, TNFAIP3, TP53, TRAF2, TRAF3, U2AF1, USP7, WT1, XBP1, XPO1, ZRSR2. Fusiones: ABL1, ABL2, AFF1, ALK, BCL2, BCL6, BCR, BIRC3, CBFB, CCND2, CCND3, CIITA, CREBBP, CRLF2, CSF1R, DEK, DUSP22, EPOR, ETV6, FGFR1, FGFR2, FGFR3, FIP1L1, FOXP1, GATA2, HLF, IL3, IRF4, JAK2, KAT6A, KMT2A, LYL1, MALT1, MECOM, MEF2D, MLLT3, MYC, MYH11, NTRK1, NTRK2, NTRK3, NUP214, PBX1, PCM1, PDGFRA, PDGFRB, PML, RARA, RUNX1, RUNX1T1, TAL1, TBL1XR1, TCF3, TCL1A, TLX1, TLX3, TP63

Estudio molecular cuantitativo de reordenamiento (BCR,ABL)

Estudio de mutaciones en el gen fusión BCR-ABL

ESTUDIO MOLECULAR GENOTIPO HLA-DPB1 (ALTA RESOLUCIÓN), SANGRE TOTAL

Cariotipo de médula ósea

FISH (BCR,ABL) t(9,22)

Secuenciación Sanger del gen CBL

Secuenciación Sanger del gen CBL

Cariotipo de médula ósea